Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vilazodone Hydrochloride (EMD 68843) 是 5-HT1A 受体和特异性 5-羟色胺再摄取抑制剂(SSRI) 的部分激动剂,用于治疗重度抑郁症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 283 | 现货 | ||
25 mg | ¥ 456 | 现货 | ||
50 mg | ¥ 592 | 现货 | ||
100 mg | ¥ 868 | 现货 | ||
200 mg | ¥ 1,280 | 现货 | ||
500 mg | ¥ 2,160 | 现货 | ||
1 g | ¥ 3,220 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 191 | 现货 |
产品描述 | Vilazodone Hydrochloride (EMD 68843) , a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder. |
体外活性 | Vilazodone demonstrates an IC50 of 0.2 nM at the human 5-HT1A receptor and 0.5 nM for the SERT. Vilazodone displays high affinity (pKi ≥ 9.3) for human recombinant and rat, guinea pig, mouse, and marmoset native tissue 5-HT1A receptors. [1] |
体内活性 | Vilazodone selectively enhances serotonergic output in the prefrontal cortex of rats. Vilazodone demonstrates anxiolytic efficacy through Behavioral evaluations in the ultrasonic vocalization model of anxiety in rats. Vilazodone also shows efficacy but at a single dose only in the forced swim test (a putative model of depression). [1] Vilazodone (1-10 mg/kg p.o.) dose-dependently displaces in vivo [3H]DASB (N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine) binding from rat cortex and hippocampus, indicating that vilazodone occupies 5-HT transporters in vivo. Vilazodone (10 mg/kg p.o.) is demonstrated to cause a 2-fold increase in extracellular 5-HT but no change in noradrenaline or dopamine levels in frontal cortex of freely moving rats. [2] Vilazodone affects stress potentiation of startle at doses above 5 mg/kg in rats. Vilazodone increases stress elevation of startle at 10 mg/kg in rats. Vilazodone (20 and 40 mg/kg) blocked stress potentiation of startle in rats. Vilazodone increases stress elevation of startle at all doses in rats. [3] vilazodone has no effect on 5-HT efflux at 100 nM but significantly decreases 5-HT efflux at 1 mM in the guinea-pig dorsal raphe nucleus. Vilazodone significantly increases the re-uptake half life for 5-HT in the guinea-pig dorsal raphe nucleus. [4] |
别名 | 盐酸维拉佐酮, SB659746A, EMD 68843, Vilazodone HCl |
分子量 | 477.99 |
分子式 | C26H27N5O2·HCl |
CAS No. | 163521-08-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (94.14 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.0921 mL | 10.4605 mL | 20.9209 mL | 52.3023 mL |
5 mM | 0.4184 mL | 2.0921 mL | 4.1842 mL | 10.4605 mL | |
10 mM | 0.2092 mL | 1.046 mL | 2.0921 mL | 5.2302 mL | |
20 mM | 0.1046 mL | 0.523 mL | 1.046 mL | 2.6151 mL | |
50 mM | 0.0418 mL | 0.2092 mL | 0.4184 mL | 1.046 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Vilazodone Hydrochloride 163521-08-2 GPCR/G Protein Neuroscience Others Serotonin Transporter 5-HT Receptor Serotonin Receptor SERT Inhibitor 盐酸维拉佐酮 inhibit SB659746A Vilazodone 5-HTT 5-hydroxytryptamine Receptor EMD-68843 EMD68843 EMD 68843 SLC6A4 Vilazodone HCl inhibitor